Louisville Cardinals vs Syracuse Orange Picks and Predictions

Louisville Cardinals vs Syracuse Orange Best Betting Picks

Louisville Cardinals
Line: -14.5 Total: o55.5 Score: 0

Syracuse Orange
Line: +14.5 Total: u55.5 Score: 0

Make your bets before 7:30pm EST 10/17/2026

Best Bets for the Louisville Cardinals vs Syracuse Orange

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the Louisville Cardinals and/or Syracuse Orange games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	Pete Mac	29-17 (63%), +$5,160	42-30 (58%), +$4,485	100%	View Website
#2	David Lagos	14-16 (47%), -$1,710	28-22 (56%), +$2,040	100%	View Website
#3	George Hampton	13-12 (52%), +$70	20-18 (53%), +$290	83%	View Website
#4	Lyle Clark	23-14 (62%), +$3,685	35-17 (67%), +$8,010	75%	View Website
#5	Brandon Donelly	22-15 (59%), +$2,775	31-21 (60%), +$3,995	75%	View Website

Vegas Trends and Betting Odds

Louisville Cardinals have won the past 3 out of 5 games (3 of 5 ATS) while the Syracuse Orange have won the past 2 out of 5 games (2 of 5 ATS). The Louisville Cardinals are 2 and 3 on the most recent away games while the Syracuse Orange are 1 and 4 at home. Vegas has the line at Louisville Cardinals -14.5 and the total at 55.5.

More hot bets: Nevada Wolf Pack @ North Dakota State Bison, Navy Midshipmen @ UTSA Roadrunners, or Western Michigan Broncos @ Central Michigan Chippewas.