San Francisco 49ers vs Arizona Cardinals Picks and Predictions

San Francisco 49ers vs Arizona Cardinals Best Betting Picks

San Francisco 49ers
Line: -3.5 Total: o48.5 Score: 0

Arizona Cardinals
Line: +3.5 Total: u48.5 Score: 0

Make your bets before 4:05pm EST 11/16/2025

Best Bets for the San Francisco 49ers vs Arizona Cardinals

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the San Francisco 49ers and/or Arizona Cardinals games and their overall NFL rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NFL Record	NFL Season Record	Hit Rate	Website
#1	Russell Davis	15-6 (71%), +$4,300	36-18 (67%), +$8,240	100%	View Website
#2	Tyler Samuels	20-13 (61%), +$3,000	41-33 (55%), +$2,555	100%	View Website
#3	Teddy Vintage	14-8 (64%), +$2,640	36-26 (58%), +$4,065	100%	View Website
#4	Richie Law	14-9 (61%), +$2,200	35-25 (58%), +$3,865	100%	View Website
#5	Ronald Manney	12-8 (60%), +$1,800	42-20 (68%), +$10,175	100%	View Website

Vegas Trends and Betting Odds

San Francisco 49ers have won the past 2 out of 5 games (2 of 5 ATS) while the Arizona Cardinals have won the past 1 out of 5 games (3 of 5 ATS). The San Francisco 49ers are 3 and 2 on the most recent away games while the Arizona Cardinals are 2 and 3 at home. Vegas has the line at San Francisco 49ers -3.5 and the total at 48.5.

More hot bets: Los Angeles Chargers @ Jacksonville Jaguars, Texas A&M-Corpus Christi Islanders @ Oklahoma State Cowboys, or Nashville Predators @ Pittsburgh Penguins.