Clemson Tigers vs Louisville Cardinals Picks and Predictions

Clemson Tigers vs Louisville Cardinals Best Betting Picks

Clemson Tigers
Line: +1.5 Total: o51.5 Score: 0

Louisville Cardinals
Line: -1.5 Total: u51.5 Score: 0

Make your bets before 7:30pm EST 11/14/2025

Best Bets for the Clemson Tigers vs Louisville Cardinals

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the Clemson Tigers and/or Louisville Cardinals games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	Ronald Manney	30-8 (79%), +$10,650	50-37 (57%), +$4,795	100%	View Website
#2	Angelo Benedetta	39-19 (67%), +$9,075	73-52 (58%), -$40,915	100%	View Website
#3	Toby Blair	29-11 (73%), +$8,500	51-41 (55%), +$3,355	100%	View Website
#4	Tyler Samuels	34-18 (65%), +$7,225	73-49 (60%), -$14,415	100%	View Website
#5	Chris Murphy	27-12 (69%), +$6,850	55-35 (61%), +$8,410	100%	View Website

Vegas Trends and Betting Odds

Clemson Tigers have won the past 3 out of 5 games (3 of 5 ATS) while the Louisville Cardinals have won the past 3 out of 5 games (2 of 5 ATS). The Clemson Tigers are 3 and 2 on the most recent away games while the Louisville Cardinals are 3 and 2 at home. Vegas has the line at Louisville Cardinals -1.5 and the total at 51.5.

More hot bets: Pittsburgh Penguins @ Nashville Predators, Lehigh Mountain Hawks @ Rutgers Scarlet Knights, or Georgia Tech Yellow Jackets @ Georgia Bulldogs.