SMU Mustangs vs Clemson Tigers Picks and Predictions

SMU Mustangs vs Clemson Tigers Best Betting Picks

SMU Mustangs
Line: +3.5 Total: o49.5 Score: 0

Clemson Tigers
Line: -3.5 Total: u49.5 Score: 0

Make your bets before 3:30pm EST 10/18/2025

Best Bets for the SMU Mustangs vs Clemson Tigers

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the SMU Mustangs and/or Clemson Tigers games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	"King" Jon Sanderson	31-11 (74%), +$9,435	49-27 (64%), +$9,590	0%	View Website
#2	Dave McGreggor	17-10 (63%), +$3,115	28-23 (55%), +$1,705	0%	View Website
#3	Nathan Skinner	19-12 (61%), +$2,630	31-23 (57%), +$2,700	0%	View Website
#4	Robert Downes	25-19 (57%), +$2,085	47-30 (61%), +$7,470	0%	View Website
#5	Micky "Bullzeye" Ferris	18-13 (58%), +$1,820	27-29 (48%), -$2,630	100%	View Website

Vegas Trends and Betting Odds

SMU Mustangs have won the past 3 out of 5 games (1 of 5 ATS) while the Clemson Tigers have won the past 3 out of 5 games (2 of 5 ATS). The SMU Mustangs are 3 and 2 on the most recent away games while the Clemson Tigers are 1 and 4 at home. Vegas has the line at Clemson Tigers -3.5 and the total at 49.5.

More hot bets: Nevada Wolf Pack @ New Mexico Lobos, Washington State Cougars @ Virginia Cavaliers, or Georgia State Panthers @ Georgia Southern Eagles.