NCAAB Matchups 12/21/2025

View a matchup to see picks from expert NCAAB handicappers.

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Final 6:00 pm EDT — Game is Complete Sunday, December 21, 2025

Iowa State Cyclones is favored -37.5. Total is 149.5.

Last 5: 1/5 (4/5 ATS)
Last 5: 5/5 (2/5 ATS)

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Final 6:00 pm EDT — Game is Complete Sunday, December 21, 2025

San Francisco Dons is favored -25.5. Total is 145.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 4/5 (5/5 ATS)

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Final 6:00 pm EDT — Game is Complete Sunday, December 21, 2025

Idaho State Bengals is favored -5.5. Total is 143.5.

Last 5: 2/5 (3/5 ATS)
Last 5: 3/5 (4/5 ATS)

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Final 5:00 pm EDT — Game is Complete Sunday, December 21, 2025

California Golden Bears is favored -8.5. Total is 152.5.

Last 5: 3/5 (1/5 ATS)
Last 5: 5/5 (2/5 ATS)

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Final 5:00 pm EDT — Game is Complete Sunday, December 21, 2025

Wichita State Shockers is favored -14.5. Total is 148.5.

Last 5: 2/5 (3/5 ATS)
Last 5: 3/5 (2/5 ATS)

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Final 5:00 pm EDT — Game is Complete Sunday, December 21, 2025

Illinois State Redbirds is favored -13.5. Total is 152.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 4/5 (3/5 ATS)

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Final 5:00 pm EDT — Game is Complete Sunday, December 21, 2025

Milwaukee Panthers is favored -6.5. Total is 160.5.

Last 5: 3/5 (2/5 ATS)
Last 5: 0/5 (1/5 ATS)

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Final 4:30 pm EDT — Game is Complete Sunday, December 21, 2025

UConn Huskies is favored -12.5. Total is 134.5.

Last 5: 5/5 (2/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

Evansville Purple Aces is favored -1.5. Total is 141.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 1/5 (3/5 ATS)

Open 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

Texas A&M Aggies is favored -28.5. Total is 165.5.

Last 5: /5 (/5 ATS)
Last 5: 2/5 (2/5 ATS)

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Final 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

TCU Horned Frogs is favored -29.5. Total is 142.5.

Last 5: 1/5 (3/5 ATS)
Last 5: 4/5 (1/5 ATS)

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Final 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

Michigan Wolverines is favored -40.5. Total is 155.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 5/5 (4/5 ATS)

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Final 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

Miami Hurricanes is favored -36.5. Total is 171.5.

Last 5: 0/5 (2/5 ATS)
Last 5: 5/5 (3/5 ATS)

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Final 4:00 pm EDT — Game is Complete Sunday, December 21, 2025

New Mexico State Aggies is favored -5.5. Total is 153.5.

Last 5: 3/5 (4/5 ATS)
Last 5: 2/5 (2/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Chattanooga Mocs is favored -2.5. Total is 138.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Clemson Tigers is favored -3.5. Total is 140.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 3/5 (2/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Cornell Big Red is favored -6.5. Total is 167.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 1/5 (2/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Saint Louis Billikens is favored -34.5. Total is 157.5.

Last 5: 2/5 (4/5 ATS)
Last 5: 5/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Incarnate Word Cardinals is favored -6.5. Total is 140.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

Arizona State Sun Devils is favored -12.5. Total is 147.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

South Florida Bulls is favored -22.5. Total is 160.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Sunday, December 21, 2025

UAB Blazers is favored -12.5. Total is 151.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 2:30 pm EDT — Game is Complete Sunday, December 21, 2025

Radford Highlanders is favored -11.5. Total is 158.5.

Last 5: 1/5 (3/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

Oklahoma State Cowboys is favored -19.5. Total is 177.5.

Last 5: 2/5 (3/5 ATS)
Last 5: 4/5 (1/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

SMU Mustangs is favored -24.5. Total is 156.5.

Last 5: 1/5 (3/5 ATS)
Last 5: 3/5 (2/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

Furman Paladins is favored -10.5. Total is 155.5.

Last 5: 4/5 (5/5 ATS)
Last 5: 4/5 (2/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

Alabama Crimson Tide is favored -20.5. Total is 182.5.

Last 5: 3/5 (4/5 ATS)
Last 5: 4/5 (1/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

George Mason Patriots is favored -23.5. Total is 145.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 4/5 (1/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

Drexel Dragons is favored -10.5. Total is 129.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 2:00 pm EDT — Game is Complete Sunday, December 21, 2025

Murray State Racers is favored -5.5. Total is 155.5.

Last 5: 5/5 (4/5 ATS)
Last 5: 1/5 (3/5 ATS)

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