NFL Matchups 9/21/2025

View a matchup to see picks from expert NFL handicappers.

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Final 1:00 pm EDT — Game is Complete Sunday, September 21, 2025

Tampa Bay is favored -6. Total is 42.5.

Last 5: 0/5 (2/5 ATS)
Last 5: 3/5 (2/5 ATS)

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Final 1:00 pm EDT — Game is Complete Sunday, September 21, 2025

is favored . Total is 44.

Last 5: 4/5 (3/5 ATS)
Last 5: 2/5 (2/5 ATS)

MLB Matchups 9/21/2025

View a matchup to see picks from expert MLB handicappers.

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Final 7:10 pm EDT — Game is Complete Sunday, September 21, 2025

Seattle is favored -138. Total is 8.5.

Last 5: 2/5
Last 5: 3/5

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Final 4:10 pm EDT — Game is Complete Sunday, September 21, 2025

Philadelphia is favored -125. Total is 8.5.

Last 5: 4/5
Last 5: 0/5

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Final 4:10 pm EDT — Game is Complete Sunday, September 21, 2025

Los Angeles is favored -194. Total is 9.5.

Last 5: 4/5
Last 5: 5/5

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Final 3:10 pm EDT — Game is Complete Sunday, September 21, 2025

Colorado is favored -104. Total is 11.5.

Last 5: 2/5
Last 5: 0/5

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Final 2:15 pm EDT — Game is Complete Sunday, September 21, 2025

Milwaukee is favored -127. Total is 8.5.

Last 5: 2/5
Last 5: 1/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

Cleveland is favored -127. Total is 8.5.

Last 5: 3/5
Last 5: 2/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

San Diego is favored -163. Total is 8.5.

Last 5: 4/5
Last 5: 2/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

Toronto is favored -117. Total is 8.5.

Last 5: 4/5
Last 5: 3/5

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Final 1:40 pm EDT — Game is Complete Sunday, September 21, 2025

Cincinnati is favored -117. Total is 9.

Last 5: 4/5
Last 5: 3/5

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Final 1:40 pm EDT — Game is Complete Sunday, September 21, 2025

New York is favored -245. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

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Final 1:35 pm EDT — Game is Complete Sunday, September 21, 2025

New York is favored -122. Total is 8.5.

Last 5: 4/5
Last 5: 1/5

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Final 1:10 pm EDT — Game is Complete Sunday, September 21, 2025

Detroit is favored -108. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

NCAAF Matchups 9/20/2025

View a matchup to see picks from expert NCAAF handicappers.

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Final 11:00 pm EDT — Game is Complete Saturday, September 20, 2025

USC is favored -18.5. Total is 55.5.

Last 5: 3/5 (0/5 ATS)
Last 5: 4/5 (2/5 ATS)

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Final 10:30 pm EDT — Game is Complete Saturday, September 20, 2025

San Diego State is favored -14.5. Total is 46.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 1/5 (1/5 ATS)

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Final 10:15 pm EDT — Game is Complete Saturday, September 20, 2025

Colorado is favored -12.5. Total is 45.5.

Last 5: 2/5 (3/5 ATS)
Last 5: 3/5 (2/5 ATS)

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Final 9:30 pm EDT — Game is Complete Saturday, September 20, 2025

UT San Antonio is favored -4.5. Total is 58.5.

Last 5: 2/5 (4/5 ATS)
Last 5: 1/5 (2/5 ATS)

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Final 9:00 pm EDT — Game is Complete Saturday, September 20, 2025

Louisiana Monroe is favored -6.5. Total is 47.5.

Last 5: 1/5 (0/5 ATS)
Last 5: 1/5 (3/5 ATS)

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Final 8:00 pm EDT — Game is Complete Saturday, September 20, 2025

Texas is favored -39.5. Total is 51.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 3/5 (0/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Baylor is favored -2.5. Total is 59.5.

Last 5: 3/5 (5/5 ATS)
Last 5: 2/5 (2/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

BYU is favored -6.5. Total is 49.5.

Last 5: 4/5 (3/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Miami is favored -7.5. Total is 50.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Vanderbilt is favored -27.5. Total is 53.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 5/5 (4/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Indiana is favored -6.5. Total is 52.5.

Last 5: 4/5 (4/5 ATS)
Last 5: 4/5 (2/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Louisiana Tech is favored -3.5. Total is 50.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 3/5 (4/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Virginia is favored -16.5. Total is 49.5.

Last 5: 1/5 (0/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 7:30 pm EDT — Game is Complete Saturday, September 20, 2025

Washington is favored -21.5. Total is 51.5.

Last 5: 2/5 (1/5 ATS)
Last 5: 1/5 (2/5 ATS)

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Final 7:00 pm EDT — Game is Complete Saturday, September 20, 2025

Boise State is favored -11.5. Total is 51.5.

Last 5: 3/5 (2/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 7:00 pm EDT — Game is Complete Saturday, September 20, 2025

South Alabama is favored -15.5. Total is 51.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 1/5 (3/5 ATS)

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