NCAAF Matchups 11/22/2025

View a matchup to see picks from expert NCAAF handicappers.

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Final 4:15 pm EDT — Game is Complete Saturday, November 22, 2025

South Carolina Gamecocks is favored -24.5. Total is 50.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 1/5 (3/5 ATS)

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Final 4:00 pm EDT — Game is Complete Saturday, November 22, 2025

Troy Trojans is favored -9.5. Total is 51.5.

Last 5: 0/5 (1/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 4:00 pm EDT — Game is Complete Saturday, November 22, 2025

Utah Utes is favored -17.5. Total is 52.5.

Last 5: 3/5 (2/5 ATS)
Last 5: 5/5 (3/5 ATS)

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Final 4:00 pm EDT — Game is Complete Saturday, November 22, 2025

Michigan Wolverines is favored -13.5. Total is 46.5.

Last 5: 4/5 (1/5 ATS)
Last 5: 0/5 (0/5 ATS)

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Final 4:00 pm EDT — Game is Complete Saturday, November 22, 2025

UCF Knights is favored -13.5. Total is 47.5.

Last 5: 0/5 (4/5 ATS)
Last 5: 1/5 (0/5 ATS)

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Final 4:00 pm EDT — Game is Complete Saturday, November 22, 2025

TCU Horned Frogs is favored -1.5. Total is 55.5.

Last 5: 3/5 (2/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:45 pm EDT — Game is Complete Saturday, November 22, 2025

Tulane Green Wave is favored -8.5. Total is 54.5.

Last 5: 4/5 (2/5 ATS)
Last 5: 1/5 (1/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Texas Longhorns is favored -10.5. Total is 57.5.

Last 5: 0/5 (1/5 ATS)
Last 5: 4/5 (1/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Duke Blue Devils is favored -6.5. Total is 49.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 2/5 (2/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

UTSA Roadrunners is favored -1.5. Total is 62.5.

Last 5: 4/5 (3/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Florida International Panthers is favored -2.5. Total is 55.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 4/5 (4/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Vanderbilt Commodores is favored -6.5. Total is 53.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 4/5 (5/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Iowa Hawkeyes is favored -17.5. Total is 43.5.

Last 5: 1/5 (4/5 ATS)
Last 5: 3/5 (4/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Southern Miss Golden Eagles is favored -2.5. Total is 52.5.

Last 5: 2/5 (1/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Notre Dame Fighting Irish is favored -36.5. Total is 50.5.

Last 5: 0/5 (1/5 ATS)
Last 5: 5/5 (3/5 ATS)

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Final 3:30 pm EDT — Game is Complete Saturday, November 22, 2025

Oregon Ducks is favored -10.5. Total is 59.5.

Last 5: 4/5 (1/5 ATS)
Last 5: 5/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Saturday, November 22, 2025

Liberty Flames is favored -1.5. Total is 45.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Saturday, November 22, 2025

UTEP Miners is favored -4.5. Total is 44.5.

Last 5: 1/5 (3/5 ATS)
Last 5: 0/5 (0/5 ATS)

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Final 3:00 pm EDT — Game is Complete Saturday, November 22, 2025

Middle Tennessee Blue Raiders is favored -6.5. Total is 53.5.

Last 5: 2/5 (2/5 ATS)
Last 5: 2/5 (3/5 ATS)

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Final 3:00 pm EDT — Game is Complete Saturday, November 22, 2025

South Florida Bulls is favored -22.5. Total is 68.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 1/5 (1/5 ATS)

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Final 3:00 pm EDT — Game is Complete Saturday, November 22, 2025

UConn Huskies is favored -6.5. Total is 63.5.

Last 5: 4/5 (3/5 ATS)
Last 5: 1/5 (4/5 ATS)

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Final 2:30 pm EDT — Game is Complete Saturday, November 22, 2025

Marshall Thundering Herd is favored -3.5. Total is 57.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 1/5 (3/5 ATS)

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Final 2:00 pm EDT — Game is Complete Saturday, November 22, 2025

Toledo Rockets is favored -28.5. Total is 45.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 4/5 (4/5 ATS)

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Final 2:00 pm EDT — Game is Complete Saturday, November 22, 2025

Alabama Crimson Tide is favored -50. Total is 57.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 2:00 pm EDT — Game is Complete Saturday, November 22, 2025

Auburn Tigers is favored -27. Total is 50.5.

Last 5: 1/5 (2/5 ATS)
Last 5: 2/5 (2/5 ATS)

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Final 2:00 pm EDT — Game is Complete Saturday, November 22, 2025

Kennesaw State Owls is favored -6.5. Total is 55.5.

Last 5: 3/5 (3/5 ATS)
Last 5: 4/5 (3/5 ATS)

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Final 2:00 pm EDT — Game is Complete Saturday, November 22, 2025

Wyoming Cowboys is favored -6.5. Total is 39.5.

Last 5: 2/5 (3/5 ATS)
Last 5: 1/5 (2/5 ATS)

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Final 1:00 pm EDT — Game is Complete Saturday, November 22, 2025

Arizona Wildcats is favored -6.5. Total is 61.5.

Last 5: 1/5 (1/5 ATS)
Last 5: 4/5 (3/5 ATS)

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Final 1:00 pm EDT — Game is Complete Saturday, November 22, 2025

Old Dominion Monarchs is favored -9.5. Total is 62.5.

Last 5: 5/5 (3/5 ATS)
Last 5: 3/5 (3/5 ATS)

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Final 1:00 pm EDT — Game is Complete Saturday, November 22, 2025

James Madison Dukes is favored -14.5. Total is 44.5.

Last 5: 3/5 (4/5 ATS)
Last 5: 5/5 (2/5 ATS)

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