MLB Matchups 9/16/2025

View a matchup to see picks from expert MLB handicappers.

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Final 7:40 pm EDT — Game is Complete Tuesday, September 16, 2025

Chicago is favored -104. Total is 8.

Last 5: 1/5
Last 5: 2/5

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Final 7:40 pm EDT — Game is Complete Tuesday, September 16, 2025

Milwaukee is favored -245. Total is 8.5.

Last 5: 4/5
Last 5: 1/5

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Final 7:40 pm EDT — Game is Complete Tuesday, September 16, 2025

New York is favored -156. Total is 9.

Last 5: 2/5
Last 5: 2/5

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Final 7:40 pm EDT — Game is Complete Tuesday, September 16, 2025

Seattle is favored -131. Total is 8.5.

Last 5: 1/5
Last 5: 2/5

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Final 7:35 pm EDT — Game is Complete Tuesday, September 16, 2025

Tampa Bay is favored -104. Total is 8.

Last 5: 1/5
Last 5: 2/5

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Final 7:10 pm EDT — Game is Complete Tuesday, September 16, 2025

New York is favored -113. Total is 8.

Last 5: 2/5
Last 5: 2/5

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Final 6:45 pm EDT — Game is Complete Tuesday, September 16, 2025

Atlanta is favored -170. Total is 7.

Last 5: 4/5
Last 5: 2/5

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Final 6:45 pm EDT — Game is Complete Tuesday, September 16, 2025

Boston is favored -144. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

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Final 6:40 pm EDT — Game is Complete Tuesday, September 16, 2025

Pittsburgh is favored -117. Total is 6.5.

Last 5: 2/5
Last 5: 3/5

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Final 6:40 pm EDT — Game is Complete Tuesday, September 16, 2025

Detroit is favored -127. Total is 8.

Last 5: 2/5
Last 5: 2/5

Past MLB Picks