MLB Matchups 9/22/2025

View a matchup to see picks from expert MLB handicappers.

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Final 9:40 pm EDT — Game is Complete Monday, September 22, 2025

Milwaukee Brewers is favored -110. Total is 7.5.

Last 5: 2/5
Last 5: 4/5

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Final 7:15 pm EDT — Game is Complete Monday, September 22, 2025

Atlanta Braves is favored -255. Total is 7.5.

Last 5: 2/5
Last 5: 2/5

MLB Matchups 9/21/2025

View a matchup to see picks from expert MLB handicappers.

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Final 7:10 pm EDT — Game is Complete Sunday, September 21, 2025

Seattle is favored -138. Total is 8.5.

Last 5: 2/5
Last 5: 3/5

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Final 4:10 pm EDT — Game is Complete Sunday, September 21, 2025

Philadelphia is favored -125. Total is 8.5.

Last 5: 4/5
Last 5: 0/5

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Final 4:10 pm EDT — Game is Complete Sunday, September 21, 2025

Los Angeles is favored -194. Total is 9.5.

Last 5: 4/5
Last 5: 5/5

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Final 3:10 pm EDT — Game is Complete Sunday, September 21, 2025

Colorado is favored -104. Total is 11.5.

Last 5: 2/5
Last 5: 0/5

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Final 2:15 pm EDT — Game is Complete Sunday, September 21, 2025

Milwaukee is favored -127. Total is 8.5.

Last 5: 2/5
Last 5: 1/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

Cleveland is favored -127. Total is 8.5.

Last 5: 3/5
Last 5: 2/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

San Diego is favored -163. Total is 8.5.

Last 5: 4/5
Last 5: 2/5

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Final 2:10 pm EDT — Game is Complete Sunday, September 21, 2025

Toronto is favored -117. Total is 8.5.

Last 5: 4/5
Last 5: 3/5

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Final 1:40 pm EDT — Game is Complete Sunday, September 21, 2025

Cincinnati is favored -117. Total is 9.

Last 5: 4/5
Last 5: 3/5

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Final 1:40 pm EDT — Game is Complete Sunday, September 21, 2025

New York is favored -245. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

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Final 1:35 pm EDT — Game is Complete Sunday, September 21, 2025

New York is favored -122. Total is 8.5.

Last 5: 5/5
Last 5: 1/5

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Final 1:10 pm EDT — Game is Complete Sunday, September 21, 2025

Detroit is favored -108. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

MLB Matchups 9/20/2025

View a matchup to see picks from expert MLB handicappers.

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Final 9:10 pm EDT — Game is Complete Saturday, September 20, 2025

Los Angeles is favored -223. Total is 8.5.

Last 5: 4/5
Last 5: 5/5

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Final 8:10 pm EDT — Game is Complete Saturday, September 20, 2025

Los Angeles is favored -117. Total is 8.5.

Last 5: 2/5
Last 5: 0/5

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Final 8:10 pm EDT — Game is Complete Saturday, September 20, 2025

Arizona is favored -104. Total is 8.5.

Last 5: 4/5
Last 5: 0/5

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Final 7:15 pm EDT — Game is Complete Saturday, September 20, 2025

Milwaukee is favored -133. Total is 8.5.

Last 5: 2/5
Last 5: 1/5

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Final 7:10 pm EDT — Game is Complete Saturday, September 20, 2025

Cleveland is favored -104. Total is 7.5.

Last 5: 3/5
Last 5: 2/5

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Final 7:10 pm EDT — Game is Complete Saturday, September 20, 2025

San Diego is favored -167. Total is 8.

Last 5: 4/5
Last 5: 2/5

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Final 7:10 pm EDT — Game is Complete Saturday, September 20, 2025

Seattle is favored -104. Total is 7.5.

Last 5: 2/5
Last 5: 3/5

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Final 7:10 pm EDT — Game is Complete Saturday, September 20, 2025

Toronto is favored -122. Total is 8.

Last 5: 4/5
Last 5: 3/5

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Final 7:05 pm EDT — Game is Complete Saturday, September 20, 2025

Tampa Bay is favored -106. Total is 8.

Last 5: 3/5
Last 5: 1/5

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Final 7:05 pm EDT — Game is Complete Saturday, September 20, 2025

Texas is favored -136. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

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Final 7:05 pm EDT — Game is Complete Saturday, September 20, 2025

New York is favored -170. Total is 9.

Last 5: 5/5
Last 5: 1/5

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Final 6:40 pm EDT — Game is Complete Saturday, September 20, 2025

Cincinnati is favored -108. Total is 9.

Last 5: 4/5
Last 5: 3/5

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Final 6:40 pm EDT — Game is Complete Saturday, September 20, 2025

Oakland is favored -104. Total is 8.

Last 5: 2/5
Last 5: 3/5

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Final 4:10 pm EDT — Game is Complete Saturday, September 20, 2025

New York is favored -245. Total is 8.5.

Last 5: 2/5
Last 5: 2/5

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Final 2:10 pm EDT — Game is Complete Saturday, September 20, 2025

Minnesota is favored -116. Total is 8.

Last 5: 3/5
Last 5: 2/5

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Final 1:10 pm EDT — Game is Complete Saturday, September 20, 2025

Detroit is favored -117. Total is 9.

Last 5: 2/5
Last 5: 2/5

Past MLB Picks