Louisville Cardinals vs Michigan State Spartans Picks and Predictions

Louisville Cardinals vs Michigan State Spartans Best Betting Picks

Louisville Cardinals
Line: +4.5 Total: o151.5 Score: 0

Michigan State Spartans
Line: -4.5 Total: u151.5 Score: 0

Make your bets before 2:45pm EST 3/21/2026

Best Bets for the Louisville Cardinals vs Michigan State Spartans

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the Louisville Cardinals and/or Michigan State Spartans games and their overall NCAAB rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAB Record	NCAAB Season Record	Hit Rate	Website
#1	James Gunnar	87-30 (74%), +$22,050	318-159 (67%), +$66,930	72%	View Website
#2	Joe Johnson	54-26 (68%), +$12,960	252-122 (67%), +$59,160	74%	View Website
#3	Brad MacKenzie	64-31 (67%), +$14,985	256-130 (66%), +$56,755	77%	View Website
#4	Tess Goldman	69-32 (68%), +$17,165	274-150 (65%), +$54,950	67%	View Website
#5	Walt Kramer "The Fox"	53-34 (61%), +$7,555	239-120 (67%), +$53,480	74%	View Website

Vegas Trends and Betting Odds

Louisville Cardinals have won the past 4 out of 5 games (3 of 5 ATS) while the Michigan State Spartans have won the past 3 out of 5 games (3 of 5 ATS). The Louisville Cardinals are 1 and 4 on the most recent away games while the Michigan State Spartans are 4 and 1 at home. Vegas has the line at Michigan State Spartans -4.5 and the total at 151.5.

More hot bets: Liberty Flames @ Nevada Wolf Pack, LA Clippers @ Dallas Mavericks, or Golden State Warriors @ Atlanta Hawks.