San Francisco 49ers vs Indianapolis Colts Picks and Predictions

San Francisco 49ers vs Indianapolis Colts Best Betting Picks

San Francisco 49ers
Line: -5.5 Total: o45.5 Score: 0

Indianapolis Colts
Line: +5.5 Total: u45.5 Score: 0

Make your bets before 8:15pm EST 12/22/2025

Best Bets for the San Francisco 49ers vs Indianapolis Colts

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the San Francisco 49ers and/or Indianapolis Colts games and their overall NFL rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NFL Record	NFL Season Record	Hit Rate	Website
#1	Kevin Fitch	19-10 (66%), +$4,095	74-35 (68%), +$18,065	0%	View Website
#2	Trevor J. Bass	25-12 (68%), +$5,910	71-34 (68%), +$17,155	40%	View Website
#3	Mathew Balance	27-18 (60%), +$3,725	93-56 (62%), +$16,505	0%	View Website
#4	Dylan Miles	17-11 (61%), +$2,385	69-34 (67%), +$15,935	0%	View Website
#5	"Slick" Rick Williams	19-13 (59%), +$2,605	70-36 (66%), +$15,485	0%	View Website

Vegas Trends and Betting Odds

San Francisco 49ers have won the past 4 out of 5 games (4 of 5 ATS) while the Indianapolis Colts have won the past 1 out of 5 games (3 of 5 ATS). The San Francisco 49ers are 3 and 2 on the most recent away games while the Indianapolis Colts are 4 and 1 at home. Vegas has the line at San Francisco 49ers -5.5 and the total at 45.5.

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