Louisville Cardinals vs SMU Mustangs Picks and Predictions

Louisville Cardinals vs SMU Mustangs Best Betting Picks

Louisville Cardinals
Line: +4.5 Total: o50.5 Score: 0

SMU Mustangs
Line: -4.5 Total: u50.5 Score: 0

Make your bets before 12:00pm EST 11/22/2025

Best Bets for the Louisville Cardinals vs SMU Mustangs

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the Louisville Cardinals and/or SMU Mustangs games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	Nate McMartin	31-15 (67%), +$7,275	63-47 (57%), +$6,030	82%	View Website
#2	Allen Barclay	30-14 (68%), +$7,250	75-47 (61%), +$11,765	0%	View Website
#3	Eli Rothstein	30-16 (65%), +$6,225	72-41 (64%), +$13,570	0%	View Website
#4	Garrett Perry	23-12 (66%), +$4,875	60-35 (63%), -$87,055	40%	View Website
#5	Teddy Vintage	19-12 (61%), +$2,875	47-37 (56%), +$3,435	100%	View Website

Vegas Trends and Betting Odds

Louisville Cardinals have won the past 3 out of 5 games (2 of 5 ATS) while the SMU Mustangs have won the past 4 out of 5 games (4 of 5 ATS). The Louisville Cardinals are 5 and 0 on the most recent away games while the SMU Mustangs are 3 and 2 at home. Vegas has the line at SMU Mustangs -4.5 and the total at 50.5.

More hot bets: Miami Hurricanes @ Virginia Tech Hokies, Long Island University Sharks @ Illinois Fighting Illini, or Tennessee Volunteers @ Florida Gators.