Pittsburgh Panthers vs Syracuse Orange Picks and Predictions

Pittsburgh Panthers vs Syracuse Orange Best Betting Picks

Pittsburgh Panthers
Line: -9.5 Total: o54.5 Score: 0

Syracuse Orange
Line: +9.5 Total: u54.5 Score: 0

Make your bets before 7:30pm EST 10/18/2025

Best Bets for the Pittsburgh Panthers vs Syracuse Orange

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the Pittsburgh Panthers and/or Syracuse Orange games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	Ryan Bowland	29-18 (62%), +$4,460	49-34 (59%), -$67,210	0%	View Website
#2	George Hampton	19-12 (61%), +$3,035	32-20 (62%), +$5,125	0%	View Website
#3	Swami Picks	19-15 (56%), +$1,280	35-27 (56%), -$45,665	0%	View Website
#4	Sean Archer	16-14 (53%), +$425	31-24 (56%), +$2,560	0%	View Website
#5	OB Consensus Picks	5-5 (50%), -$180	10-8 (56%), +$700	0%	View Website

Vegas Trends and Betting Odds

Pittsburgh Panthers have won the past 3 out of 5 games (3 of 5 ATS) while the Syracuse Orange have won the past 2 out of 5 games (2 of 5 ATS). The Pittsburgh Panthers are 1 and 4 on the most recent away games while the Syracuse Orange are 4 and 1 at home. Vegas has the line at Pittsburgh Panthers -9.5 and the total at 54.5.

More hot bets: Baylor Bears @ TCU Horned Frogs, USC Trojans @ Notre Dame Fighting Irish, or West Virginia Mountaineers @ UCF Knights.