USC Trojans vs Notre Dame Fighting Irish Picks and Predictions

USC Trojans vs Notre Dame Fighting Irish Best Betting Picks

USC Trojans
Line: +10.5 Total: o59.5 Score: 0

Notre Dame Fighting Irish
Line: -10.5 Total: u59.5 Score: 0

Make your bets before 7:30pm EST 10/18/2025

Best Bets for the USC Trojans vs Notre Dame Fighting Irish

Below are the top 5 sports handicappers with picks on this game. Experts are listed in order based based on their hit rate from previous picks on the USC Trojans and/or Notre Dame Fighting Irish games and their overall NCAAF rankings. Visit their website directly to purchase their best bets for the day.

Rank	Sports Handicapper	30 Day NCAAF Record	NCAAF Season Record	Hit Rate	Website
#1	Robert Downes	26-19 (58%), +$2,585	48-30 (62%), +$7,970	0%	View Website
#2	Chris Coleman	19-8 (70%), +$5,200	31-15 (67%), +$7,940	0%	View Website
#3	Abe Howland	18-14 (56%), +$1,280	37-21 (64%), +$6,985	0%	View Website
#4	Jeremy Redmond	21-12 (64%), +$3,755	38-23 (62%), +$6,540	0%	View Website
#5	George Hampton	19-12 (61%), +$3,035	32-20 (62%), +$5,125	0%	View Website

Vegas Trends and Betting Odds

USC Trojans have won the past 4 out of 5 games (2 of 5 ATS) while the Notre Dame Fighting Irish have won the past 4 out of 5 games (3 of 5 ATS). The USC Trojans are 2 and 3 on the most recent away games while the Notre Dame Fighting Irish are 3 and 2 at home. Vegas has the line at Notre Dame Fighting Irish -10.5 and the total at 59.5.

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